Lowercase characters were introduced in Unicode 8.0, to cover growing use of bicameral content in modern typesetting, as well as some older texts such as the Cherokee New Testament. The lowercase text above is likely to be displayed as tofu (boxes), since it is currently difficult to find a font that includes lowercase forms.

The shapes of the upper- vs. lower-cased letters don't change radically (as they do in Latin or Cyrillic). The lowercase letters are often simply smaller, however they may have ascenders and descenders in some fonts.

Fonts that existed prior to Unicode 8.0 need updating to support lowercase characters.

Tests & results:

This page shows Mac and Windows OS pre-installed fonts that support Cherokee and tests them for lowercase support.

Mac OS X 10.15 has:

• Plantagenet Cherokee
• Galvji
• Geneva
• Noto Sans Cherokee

All except Plantagenet Cherokee support lowercase characters.

Windows 10 has:

• Plantagenet Cherokee
• Gadugi

Gadugi is the default installed font, and it supports lowercase letters. Plantagenet Cherokee does not.

Priority:
Marking this as advanced, since most of the pre-installed fonts do support the lowercase characters. For users of the Plantagenet font, font fallback should produce visible text (although it may not match well the uppercase letters).