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Talk Python To Me

A podcast on Python and related technologies


#1
Python Podcast
11+
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Latest episode: #542 Zensical - a modern static site generator

If you've built documentation in the Python ecosystem, chances are you've used Martin Donath's work. His Material for MKDocs powers docs for FastAPI, uv, AWS, OpenAI, and tens of thousands of other projects. But when MKDocs 2.0 took a direction that would break Material and 300 ecosystem plugins, Martin went back to the drawing board. The result is Zensical: A new static site generator with a Rust core, differential builds in milliseconds instead of minutes, and a migration path designed to bring the whole community along.

Upcoming episodes

Sydney Runkle
Sydney Runkle
(up next)
Deep Agents: LangChain's SDK for Agents That Plan and Delegate

When you type a question into ChatGPT, the model only has what you typed to work with. But tools like Claude Code can plan, iterate, test, and recover from mistakes. They work more like we do. The difference is the agent harness: Planning tools, file system access, sub-agents, and carefully crafted system prompts that turn a raw LLM into something genuinely capable.

Sydney Runkle is back on Talk Python representing LangChain and their new open source library, Deep Agents: A framework for building your own deep agents with plain Python functions, middleware hooks, and MCP support. This is how the magic works under the hood.

Panelists
Panelists
(and then)
Wheel Next + Packaging PEPs

When you pip install a package with compiled code, the wheel you get is built for CPU features from 2009. Want newer optimizations like AVX2? Your installer has no way to ask for them. GPU support? You're on your own configuring special index URLs. The result is fat binaries, nearly gigabyte-sized wheels, and install pages that read like puzzle books. A coalition from NVIDIA, Astral, and QuantSight has been working on Wheel Next: A set of PEPs that let packages declare what hardware they need and let installers like uv pick the right build automatically. Just uv pip install torch and it works. I sit down with Jonathan Dekhtiar from NVIDIA, Ralf Gommers from QuantSight and the NumPy and SciPy teams, and Charlie Marsh, founder of Astral and creator of uv, to dig into all of it.

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Very substantive, polished podcast. Michael is the ideal interviewer: deeply knowledgeable and prepared, but knows how to get out of the way and let his guests dominate the conversation. Absolutely required listening for all Pythoneers IMO.
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15 Top-Notch Podcasts for Programmers & Software Developers
Talk Python to Me blows all other Python-related podcasts out of the water. The host is great, the format is great, the guests are great - there's a lot to love about it, including the actual content, which is immensely useful for Python developers.
— makeuseof.com
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I can keep myself up to date with newest tools and things that come up within the Python ecosystem, and sometimes beyond! The insights I get from the guests are invaluable. Michael always makes sure to elucidate the topic-specific jargons in human terms.
— Deep.Space
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Michael Kennedy
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About the Show

Talk Python to Me is a weekly podcast covering a wide array of Python topics as well as many related technologies. Each episode features a casual 1-hour conversation with industry experts.

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